ABSTRACT
<p><b>OBJECTIVE</b>To evaluate the effects of pulse high volume hemofiltration (PHVHF) in the treatment of multiple organ dysfunction syndrome (MODS).</p><p><b>METHODS</b>Twenty-five patients with MODS received treatment with PHVHF.</p><p><b>RESULTS</b>The 25 patients showed significantly decreased BUN, Scr, and K(+) levels after the treatment (P<0.01), and PaO(2)/FiO(2) was improved in almost all the patients (P<0.05). The APACHEII scores were significantly improved (P<0.05) in these patients and 18 of them were cured and discharged. PHVHF therapy was associated with a survival rate of 72%.</p><p><b>CONCLUSIONS</b>PHVHF can be effective for treatment of MODS.</p>
Subject(s)
Adolescent , Adult , Aged , Aged, 80 and over , Female , Humans , Male , Middle Aged , Young Adult , Hemofiltration , Methods , Intensive Care Units , Multiple Organ Failure , Therapeutics , Treatment OutcomeABSTRACT
MicroRNAs (miRNAs), with the length of about 22 nucleotides, are a growing family of small non-protein-coding RNAs that function as post-transcriptional regulators of target genes, involved in multiple processes of life and closely related with tumorigenesis. Recently, some aberrantly expressed miRNAs have been discovered in the prostate, indicating that miRNA may play a critical role in the molecular mechanism of the pathogenesis of prostate cancer. With deeper studies on human serum and plasma miRNAs, serum miRNA is promising to be a potential diagnostic biomarker for prostate cancer.